I just finished addressing a meeting in Islamabad, Pakistan -- Synthetic Biology and its Dual Use.  I was scheduled to give my talk via two-way video teleconference that turned out to be ... one-way.  So rather than being able to interact with my audience, I had to simply page through my presentation on my end and hope they were still listening.  I was basically practicing my talk, except there was a live video connection to the other side of the world.  Very strange.